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Humanization is important for reducing the immunogenicity of monoclonal antibodies derived from xenogeneic sources (commonly rodent) and for improving their activation of the human immune system. Since the development of the hybridoma technology, a large number of rodent monoclonal antibodies with specificity for antigens of therapeutic interest have been generated and characterized.
Read more »SIAT® DC-T cell proliferation assay uses Flow Cytometry to detect T cell proliferation after co-culture with loaded DCs, which is extremely sensitive and accurate. Specifically, T cells are labeled with 5,6-carboxyfluorescein diacetate succinimidyl ester (CFSE) dye.
Read more »The rabbit antibody repertoire is an exceptional source for both polyclonal antibodies and monoclonal antibodies that combine high specificity with high avidity and affinity. In addition, rabbits, which belong to the order Lagomorpha (lagomorphs), are evolutionarily distant from mice and rats, which belong to the order Rodentia (rodents).
Read more »Creative Biolabs offers an innovative custom service to produce native human monoclonal antibodies through our unique Native™ Antibody Discovery Platform.For technical reasons, current in vitro antibody display methods cannot provide human antibodies with naturally paired heavy chain and light chain. This could potentially lead to the generation of antibody molecules that have suboptimal solubility or other biophysical characteristics.
Read more »Camelid, especially camel and llama, is a kind of novel source for the research and development of antibody. Compared with other species, camelid members are the only mammals who can produce not only the conventional antibodies composed of heavy chains and light chains, but also novel antibodies only with heavy chains.
Read more »The knobs-into-holes technique is suitable for heterodimerization immunoglobulin heavy (H) chains with amino acid (AA) changes, which can overcome the mispairing problem. In order to overcome the impurity problem in tri-functional antibody production process, experts introduce a knob into the CH3 of one antibody and a corresponding hole into the CH3 of the other antibody via the alteration of AA respectively.
Read more »What is antibody?
How many kinds of native antibodies exist in vivo?
How does antibody mature in vivo?
Is there any artificial antibody and what are their applications?
What are the applications of antibody in research?
What are the applications of antibody in clinic?
What is the difference between the applications of polyclonal antibody and monoclonal antibody?
What is antigen?
What kind of antigen is suitable for immunization to generate antibody?
How does antibody bind to its target antigen?
How to determine the affinity of certain antibody to antigen?
Ecamsule protect the skin from sunburn and erythema. It causes serious eye damage, so please wear protective gloves/protective clothing/eye protection/face protection.
Synonyms[(2E)-2-[[4-[(Z)-[7,7-dimethyl-3-oxo-4-(sulfomethyl)-2-bicyclo[2.2.1]heptanylidene]methyl]phenyl]methylidene]-7,7-dimethyl-3-oxo-4-bicyclo[2.2.1]heptanyl]methanesulfonic acid; 3,3'-(1,4-phenylenedimethylidyne)bis(7,7-dimethyl-2-oxobicyclo(2.2.1)heptane-1-methanesulfonic acid); Ecamsule; Mexoryl SX; terephthalylidene dicamphor sulfonic acid; 92761-26-7; AC1O5SNJ; Ecamsule [USAN:USP:INN]; SCHEMBL119994; AKOS024464868;
Cariprazine is an orally active D2/D3 dopamine receptor antagonist exhibits high selectivity and affinity to dopamine D3(Ki=0.09 nM) and D2 (Ki=0.5 nM) receptors and moderate affinity to serotonin 5-HT(1A) receptors. It is used as an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression. It has also been used as a potential adjunct in treatment-resistant major depressive disorder.
Read more »Gadobutrol is a nonionic, paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI). It has a macrocyclic framework and is neutral. It is a water-soluble, highly hydrophilic compound with a partition coefficient between n-butanol and buffer at pH 7.6 of ~ 0.006.
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